Whenever the rainbow appears in the clouds, I will see it and remember the everlasting covenant between God and all living creatures of every kind on the earth." Genesis 9:13

Saturday, August 29, 2015

Loxapine the end

I got home from the hospital yesterday.  I wound up with a fast taper of the loxapine.  I spent 30 hours in the ER waiting for a bed (every psych bed in Cleveland Clinic was full) and getting meds Sunday night was tough and they only got 5 mg of the 10 I was supposed to have. Then Monday I didn't see a dr. for admission until midnight and the pharmacy was closed so I didn't get any.  Tuesday we agreed to just end the taper even though it was a harsh ending.

I am still feeling very depressed but I no longer want to hurt myself.  I'm home with the caveat that I might have to come back in.  The dr. said I should expect depression for at least another week, possibly 2.  My body has been through so much with the rapid loxapine withdrawl, a bunch of weirdness with my patch (it couldn't be changed for 60 hours with the ER and pharmacy being closed and then we were going to stop it and go to Nardil until I looked up what Nardil would cost out of pocket), increasing my Seroquel, etc.  So I guess feeling good may take some time.  In a few days my Seroquel can go back up and then I'll be on the same meds I was on when this started.  That scares me but it will be easier to add something later if needed and I needed to get out of the very dark place I was in first.  Adding another anti-psychotic isn't a good idea until loxapine's effects are gone.

My tongue is still moving weirdly but inside my mouth and there is no chewing motion unless I'm having spasms of the muscles in my jaw.  So that's better and in a few more weeks the rest should be gone completely after the last of the drug really works its' way out of my body and my body chemistry has had time to level out.  

So in time this will become my past and my present is taking care of myself the best I can and staying home instead of going back.  (I have a well-earned horror of spending more time in the ER any time soon.  I was there for an unusual situation but I don't ever want to do that again.  It was as good as it could be but 30 hours in a psych ER is a tough thing.  I no longer eat hamburgers because I had 2 of them cold and then refused to eat the 3rd.  So instead I had ham sandwiches that caused migraines and I didn't even care.

Anyway, loxapine is over with.

Saturday, August 22, 2015

Loxapine taper

I'm not handling this well.  I have so much less medication in my body than it is used to because my antidepressant and Seroquel doses are lower too and at home I can't increase those while tapering the loxapine.  The last week of the taper is now.  I will be going into the hospital Sunday to get help getting through the taper and hopefully onto some meds to help the horrible depression that has hit very hard in the last 2 weeks or so.

More later.....

Tuesday, August 18, 2015

loxapine-the beginning of the end

Loxapine worked very well for me.  Unfortunately it also isn't the right drug for me.  I wish that it was going to work out but the end is near.  I saw Dr. Brain today (after seeing Dr. Mind who was concerned enough to send Dr. Brain an email about me) and it's just not possible to stay on loxapine and so tonight I started coming off it.  Not only am I still having oral motor movements I am also depressed now, enough to get an offer of the hospital which I decided to not take.

The oral movements just won't stop even with lowering both the dose of it and the dose of seroquel.  Which means it is the loxapine causing it.  This week I am taking 20 mg every other day and 10 every other day and then next week will be 10 every day just to be sure that I don't have no side effects and feel good on that.  However it is very unlikely that will happen.

Since we have to know what changes the loxapine is making no other changes can be made until that it over.  Which means I am facing a couple weeks of probably feeling pretty lousy.  

I think that I'm going to get Dr. Mind to monitor the depression but I'm going to ask a question that came up at the end of the session with Dr. Brain and was only partly answered because we were over time and hurrying:  if the hospital can expedite what I'm going through I will go to the hospital next week.  This week I'm dogsitting and don't have anyone to step in for me.  I'm ok for now but worried if it gets any worse.  I don't want to go to the hospital but well, I've never been in the summer so might as well add to my collection?  Or get better as fast as possible.  This has gone on for 8 months now.  

We don't know what med we'll try next.  But if I fail one or two more I'll be going on clozaril which is the scary med.  If I go on it for a full year I have to get blood drawn every week to be sure my WBC is ok.  I only would get a week's worth of meds at a time and every week would have to have a new order until the next blood draw.  And I'd have to get off Seroquel before starting it which would be ugly and has the word hospital all over it.  It has potentially strong side effects but less likely to cause the things I've dealing with now.  It is the med of last resort and nobody wants to see that happen but I need to be on a med that works and the trick with clozaril is that it often really works.  I just don't want to be this close to having to take it.

And I am so tired....I've been sleeping 12-15 hours per day and today I had to get up for my appointments so I'm seriously tired yet not at all sleepy.  Lovely.

So that's about the end of it.

Tuesday, August 11, 2015

Loxapine update

The last time I posted I was reducing my Seroquel dose because I was having uncontrolled oral motor movements.  Unfortunately this continued and since Dr. Brain was on vacation I lowered my loxapine dose myself.  Which didn't work and then my mom and Dr. Mind started worrying about my flat affect (basically appearing to have no facial expressions).  So when Dr. Brain was due back today I left a message for her that it was continuing, I was concerned, etc. along with huge apologies because I know that it is awful when she comes back from vacation.

She called at 8:45 tonight, I think on her way home from work.  We decided to try to keep the loxapine by adjusting Seroquel and Emsam if possible.  So I'm lowering my Seroquel tonight and then will probably lower it again Thursday.  I see her Monday and that will probably be the final decrease to half the Seroquel I was taking 2 weeks ago.  

The trick is not bottoming out.  So far the flat affect is over-medication but it can happen from depression too and that would not be good.  So I have to be carefully watched for depression as I'm on less Seroquel but hopefully the same amount of medication overall.

There is no choice about this.  I have to stop the movements or I could develop TD (tardive dyskinesia) which is permanent uncontrolled movements.  No thanks.  I'm less at risk because this is happening while on the meds and not while coming off them but it is still a risk and still needs to be alleviated.   I have no desire to go through life visibly chewing nothing.

So it's a bit scary.  But my mood is ok and that's a good thing.  Some depression but there's fear and med changes involved and so it could be anything.

Off to buy my niece's 2nd birthday present.

Thursday, July 30, 2015

Loxitane continued

It's been a few weeks since I wrote about the EPS.  With Cogentin and valium I have pretty much eliminated the muscle pain.  But I'm still having issues that may be deal breakers.

I went back to my normal dose of my Emsam (MAOI) last week and during dinner my face flushed deeply.  I finally took my blood pressure and instead of my usual 103/64 it was 135/84 or something like that.  It shouldn't interact but that is what an MAOI reaction looks like so it probably was and so I had to cut the Emsam back down to 6 mg.  Which is fine now but won't be when SAD season hits and that is coming soon.  But that was just something to discuss with Dr. Brain later.  She wanted me to come down on the loxapine because I was still having muscle pain but because it was working I asked if I didn't complain until I saw her if I could stay on the dose and then in a month we had already planned to lower my Seroquel dose.

That seemed to be working until several days ago when I realized my mouth had movements that I couldn't control.  Mostly my tongue is constantly moving (it stops if I think about it but starts before I even have it back in my mouth) and my jaws are making small chewing movements.  I left it alone to see if anyone noticed from the outside and yesterday my mom did, from a distance.  And since the inside of my mouth is getting pretty chewed up and visible oral motor movements are pretty much my one thing I won't tolerate (and I think it is a bad thing that must be stopped or it can turn into tardive dyskinesia, permanent uncontrolled movements) so I emailed Dr. Brain who said she doesn't want me to suffer with EPS and I can lower the Seroquel now  and will start another med (ironically a blood pressure med) in a few weeks if this doesn't calm down.  I know what the reality is; I'm getting close to failing this drug.  I'm terrified of that; the other typical anti-psychotics are not pretty.  Loxapine hasn't been bad except for the EPS which is just something I'm more prone to getting for whatever reason.  But hopefully lowering my Seroquel fixes my brain chemistry and everything will be fine again.  Dr. Brain is on vacation so if it isn't then I'll be dealing with another dr which I dread the idea of.  

So, for now, great drug, big problems handling it.  Very disappointed because I am feeling better and hate the idea of losing that.

Tuesday, July 14, 2015

Loxapine update

I have been on loxapine for about 5 weeks now.  I really like it.  It is so different than Seroquel; it's not super sedating, it doesn't make me crave carbs (the opposite in fact), it works fast and then is out of my system, and I'm not aware all the time that I've taken it.  It is weird that I can feel it in my system through the time I've taken it until it is at peak concentration 4 hours later (the side effects are present then and then dissipate); I've never had a drug I could feel like this.  I am on 20 mg and we're aiming for 30-40 mg to be my dose we hope.  20-60 is normal.  Normal dosing is divided and I am taking it all at once because I'm not good at taking meds more than once per day and I have Seroquel to keep things level during the day so just having the added meds/sedation at night is better.

There is one problem and that is that I am having some EPS (extra-pyramidal syndrome).  Essentially there is more of some of the brain chemicals than my brain wants and this is the reaction.  You have to be really careful with this reaction because it can lead to some scary and permanent issues or a situation where the vitals become unstable and dangerous.  I've had it before on drugs much less likely to cause this so it was kind of expected; I had a prescription for treating it from the day I started the loxapine.  The problem was that I missed what was going on.  In the past EPS has been uncontrolled oral movements (my tongue flicking in and out like a snake all the time) or akasthesia which is the feeling that you have to move all the time without stopping.  I was hospitalized with that a few years ago and was afraid that would happen again since I've had it on a few drugs.  So far so good though.

What did happen was muscle rigidity.  My body has just HURT for weeks.  I kept explaining it away though; my back hurt from bending over my sewing.  My legs and feet hurt because my shoes weren't right.  My jaw hurt from grinding my teeth.  Etc.  And then suddenly Friday I realized that I wasn't just in pain my muscles were tight.  So I took some extra klonopin and nearly immediately things relaxed.  I took a big dose of valium that night and most of my pain has been gone since with a little more valium or klonopin when needed.  My jaw is still very sore and the muscles are kind of spasming.

I saw Dr. Brain today and she did a test and so we have a baseline to watch and she changed meds around.  I started Cogentin tonight, which is a med that helps with the rigidity and any other movement disorder symptoms I might get.  I'm going to be changing my nighttime benzo to valium if I can find a dose that gets me to sleep but doesn't knock me out so that I get the benefit of that too since it also treats the EPS.  And I'll monitor and we'll watch and wait and hopefully the Cogentin will fix things and I'll be tolerating this well and without pain.  I sure wish I'd realized that the pain was this before it got to my feet. That hurt so much and I kept putting the blame on my shoes because I'm still working on finding shoes that I like and that meet my very picky requirements for shoes right now with the ankle still recovering.  They must be supportive, have a thin sole so I can feel stones and things that I step on, have a wide toe box, and look ok to wear in public.  It's hard to find shoes that meet these requirements and so when I thought I'd found a pair a month ago I was thrilled and then when they started hurting so much I thought I'd wasted another chunk of money on shoes I couldn't wear.  But I was wrong and so glad to be.

Now I just have to get all the med changes done in the next few days while still maintaining the schedule I had set up ahead of time.  I have to not be too sedated but be sedated enough.  That's a fine line I do not enjoy dealing with.

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Wednesday, June 24, 2015

Good thing my favorite color is green

I still am liking loxapine.  But I had the dose increased and I am so nauseous for several hours every night.  It keeps me awake although I'm still asleep much earlier than before I started it.  

When I was initially on it the nausea passed after a few days so hopefully tonight will be better than last night.  I am not about to give up on this because it is working.  But it really is hard to take it knowing that I'll feel bad afteward.  I take it with food and last night tried taking it with MORE food but that didn't help.  I'm only on 20 mgs which is a tiny dose.  But it will work out.

I also finally figured out, I think, why I was so much worse this episode with psychosis.  I've never had a bad episode since diagnosis without lithium.  Last year after I was toxic and had to stop it I had an episode that responded quickly to a Seroquel increase and then I had a long time I was grieving/just sad about my brother but I hadn't had a bad episode that didn't respond to immediate med changes in a while.  This was the biggest difference in anything that I'm aware of so I'm pretty sure that it is connected.  Lithium always was good at helping me, I just had too many toxicities.  I guess it did even more than we knew.  I'm anxious to talk to my drs about this.

But that is over at least.  No psychosis for almost 2 weeks now and that is a blessing I hadn't truly understood before.  Before now psychosis has been intermittent and inconsistent and this time it was everything but those things.  Loxapine seems to have squelched it though even with my tiny dose.  So hopefully 2 antipsychotics makes up for no lithium although I suppose I won't know this until I have another episode.  The depressed phase of this one has hit so probably another couple of months before I'm over it fully.

I'm still not back to life as usual, mainly because of nausea and sleeping off the new dose of medication.  But it will get there eventually and I'm glad for that.

Wednesday, June 17, 2015

Loxapine

I know it's been forever.  It's been just too much to write with the paranoia, the agitation, the hallucinations, the sleeplessness.......I was in a very, very scary place for a while.  It was so bad that Dr. Mind told me I should go to see Dr Brain prepared to be admitted.  He has been really worried about admissions and that's come up a lot the last while.

Last week I started a new med.  It is actually a very old anti-psychotic.  Almost nobody uses it anymore and it's hard to find anything about it on the internet.  Most of what is out there just says the same thing that is written about all old antipsychotics. But occasionally you find that this one is a little different in that it turns into a kind of antidepressant (but not something exactly accepted as an antidepressant) on the way out so it has an antidepressant effect and Dr. Brain felt I needed that.  I was scared of it because old antipsychotics can be really scary and this one that nobody uses seemed especially scary but I am actually loving this med.  It's improved my sleep (I need a dose increase and sleep will be much better), it has stopped the psychosis as far as I can tell (nothing for several days but I've not been out of the house much), and I've lost 3 lbs in a week because it takes away my appetite.  I'm on 10 mg and you can go up to 250 so it also has a ton of room to grow.

So the risk of hospitalization is down to low again barring some weird problem and I'm feeling so much better than a week ago that I don't have words to describe it.

I still plan to take most entries on here down but I'm not really at the place where sitting and doing that sounds like fun.  I am going to keep some posts up and leave posts about loxapine up because I'd like to help someone else looking for anything about this drug besides the same generic profile.

So that's my story.

Saturday, May 30, 2015

Not gone yet

I'm not gone yet. I'm just unable to write at the moment.  I can but it takes forever and I make a lot of mistakes trying to make sense.  So I'm not doing it much.

I'm not well enough to do anything with the blog just yet.  Right now it is a fight to stay out of the hospital.  I've had so many times I've had to fight symptoms and do things but it turns out you can't control psychosis.  And I have psychosis.  Dr. Mind is pretty concerned.

I'll be back at least once more.  Who knows maybe I'll stay.  I doubt it but I have had so much horribleness going on that I can't make decisions.

Thank you again for the kind comments and understanding.

Friday, May 15, 2015

Changes

I have had a lot of time to think lately.  I'm still not sleeping very well although I am responding to my meds and doing better slowly.  Right now the big issues are that I always get manic in June so I need to get stable and hopefully avoid that and I'm still not tolerating my antidepressant except at a very low dose so I am at risk of crashing hard although everyone is watching to hopefully catch that if it starts.  I hate the side effects of the very high dose Seroquel (it makes it so that I have a great deal of difficult urinating and that is quite painful unless I wait until my bladder is so full there is no choice which is also not comfortable, plus I just don't feel good on it.)  But it is helping and my mind is slowing down enough to think.  I'll catch up on emails soon, I promise.  I saw Dr. Brain and once samples have been obtained (it's a process due to Cleveland Clinic policies) I'll be trying Latuda again.  I am hoping that it can take some of the need for Seroquel away and that I might get down to a dose that gives us options if I get sick:  raise Latuda or raise Seroquel.  Raising Seroquel is simply not an option I can tolerate any more of.  So hopefully adding a little more medication will help me function better without a lot of bad side effects.  I tried it once before without side effects but I was such a mess at that time I didn't give it a fair trial. 

I've also made a decision.  I have been blogging for 9 years and 5 months exactly as of today.  I think at this time I have said everything that I am going to have to say that is new and different.  I've loved blogging, it is great to share a story and press a button and know that people everywhere might be reading it and that maybe I've helped someone.  But that's 25% of my life.  There will always be ups and downs and episodes but they aren't going to change much.  Therefore if this blog isn't boring already and I think it is, it is certain to become so.  There will be family issues but honestly I'm not comfortable posting them online, especially with the nature of what is coming up in my life.  And so I am going to end this blog.  It will be sometime within the next 2-4 weeks and my plan is to take down all but a few posts.  Those will be left for anyone who stumbles into it to see and I will keep writing but not actually posting anything new.

I've appreciated all the support I've gotten over the years and it has meant so much that you have come and shared my mixed up, difficult stories, whether for a month or for years.  I hope that you will consider emailing me from time to time.  I don't check that email account all the time but would love to see more than junk mail when I do.  I haven't gotten to know many of you over the years and would feel privileged to have that chance.  At the same time I totally respect your privacy as I hope I always have.

I will miss this.  But it's just time to move on.  I've posted less and less in the last year with the only change being when I have felt bad and that's no fun to read.    I suppose there is always a chance I'll come back.  But I think my time is about up here.

More information to come as I figure out exactly what I'm doing, what I'm leaving up and how obnoxious it will be to get to the point that I am down to only those posts.